Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 4/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970261 | 0.83 | KDM4E (0.42) | HSD17B10KDM4EMAPTBCHEACHE | |
| SCHEMBL4970714 | 0.81 | MEN1 (0.40) | HTR6HSD17B10MAPTACHEKMT2A | |
| SCHEMBL4971283 | 0.80 | HTR6 (0.39) | HTR6KDM4EHRH1MAPTBCHE | |
| SCHEMBL4971034 | 0.77 | KMT2A (0.40) | HTR6KMT2A | |
| SCHEMBL4970200 | 0.76 | MAPT (0.43) | HTR6HSD17B10KDM4EMAPTRAB9A | |
| SCHEMBL4970766 | 0.76 | HTR6 (0.42) | HTR6HSD17B10KDM4EMAPTKMT2A | |
| SCHEMBL4970757 | 0.74 | KDM4E (0.41) | HSD17B10KDM4EMAPTBCHEACHE | |
| SCHEMBL4968166 | 0.73 | KDM4E (0.40) | HSD17B10KDM4EMAPTBCHEACHE | |
| SCHEMBL28222790 | 0.71 | BCHE (0.47) | HSD17B10KDM4EMAPTNPC1BCHE | |
| SCHEMBL4969062 | 0.70 | KDM4E (0.43) | HSD17B10KDM4EMAPTBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654228-B1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | claimed |