Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ADH1C | P00326 | 2/20 | 0.37 |
| ▸ | ADH1A | P07327 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740408 | 0.77 | ADH1A (0.41) | HRH4HRH3ADH1CADH1AKDM4E | |
| SCHEMBL7742694 | 0.77 | ADH1A (0.41) | HRH4HRH3ADH1CADH1AKDM4E | |
| SCHEMBL1582838 | 0.76 | ADH1A (0.31) | ADH1CADH1ACYP2D6SLC6A2SLC6A4 | |
| SCHEMBL14146643 | 0.75 | MAOA (0.41) | MAOAMAOB | |
| SCHEMBL4520995 | 0.74 | HRH4 (0.38) | HRH4HRH3ADH1CADH1AKDM4E | |
| SCHEMBL7139255 | 0.74 | ADH1A (0.39) | ADH1CADH1AKDM4ESIGMAR1ALDH1A1 | |
| SCHEMBL13296390 | 0.74 | HRH3 (0.39) | HRH4HRH3ADH1CADH1AKDM4E | |
| SCHEMBL15600812 | 0.73 | HRH4 (0.37) | HRH4HRH3ADH1CADH1AKDM4E | |
| SCHEMBL7447366 | 0.72 | ADH1C (0.38) | ADH1CADH1A | |
| SCHEMBL25934757 | 0.72 | HRH4 (0.34) | HRH4HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753723-B1 | SUBSTITUTED QUINOLINE DERIVATIVES AS MITOTIC KINESIN INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-08-13 | — | — | EP | claimed |
| CN-1210250-C | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI SYNTHELABO (FR) | 2005-07-13 | — | — | CN | disclosed |
| US-6482986-B1 | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2002-11-19 | — | — | US | disclosed |
| CN-1355782-A | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI SYNTHELABO (FR) | 2002-06-26 | — | — | CN | disclosed |
| EP-1192122-A1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076953-A1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2000-12-21 | — | — | WO | disclosed |
| US-4088772-A | TRANQUILIZERS, ANALGESICS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1978-05-09 | — | — | US | disclosed |
| US-4077977-A | Ethenoanthracenes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1978-03-07 | — | — | US | disclosed |
| US-4076830-A | TRANQUILIZERS, ANALGESICS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1978-02-28 | — | — | US | disclosed |