Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 1/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 7/20 | 0.37 |
| ▸ | SCD | O00767 | 4/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972649 | 0.84 | SCD5 (0.47) | TRPC3TRPC6HTR2CSCDSCD5 | |
| SCHEMBL4973530 | 0.82 | TRPC3 (0.42) | TRPC3TRPC6HTR2CSCDSCD5 | |
| SCHEMBL27730543 | 0.81 | TRPC3 (0.40) | TRPC3TRPC6HTR2CSCDSCD5 | |
| SCHEMBL27730542 | 0.79 | TRPC3 (0.41) | TRPC3TRPC6HTR2CSCDSCD5 | |
| SCHEMBL4970437 | 0.77 | SCD5 (0.49) | TRPC3TRPC6HTR2CSCDSCD5 | |
| SCHEMBL4970307 | 0.76 | CNR1 (0.43) | TRPC3TRPC6HTR2CSCD5NPC1 | |
| SCHEMBL4973462 | 0.75 | HTR2C (0.60) | HTR2CNPC1RAB9A | |
| SCHEMBL4974086 | 0.75 | HTR2C (0.60) | HTR2CNPC1RAB9A | |
| SCHEMBL4973873 | 0.74 | RAB9A (0.43) | TRPC3TRPC6HTR2CNPC1RAB9A | |
| SCHEMBL4972781 | 0.74 | HTR2C (0.38) | TRPC3TRPC6HTR2CCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | claimed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | claimed |
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |