Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.44 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972171 | 0.91 | SPR (0.44) | SCD5RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL4970419 | 0.83 | HTR2C (0.46) | RAB9ANPC1HTR2CTRPC3TRPC6 | |
| SCHEMBL4971657 | 0.83 | HTR2C (0.44) | HTR2CTRPC3TRPC6 | |
| SCHEMBL4974086 | 0.83 | HTR2C (0.60) | RAB9ANPC1MAPTSMN1; SMN2HTR2C | |
| SCHEMBL4973462 | 0.83 | HTR2C (0.60) | RAB9ANPC1MAPTSMN1; SMN2HTR2C | |
| SCHEMBL4971490 | 0.83 | HTR2C (0.42) | SCD5SCDHTR2C | |
| SCHEMBL5661659 | 0.81 | SCD5 (0.52) | SCD5RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL4973944 | 0.78 | HPGD (0.42) | RAB9ANPC1MAPTSMN1; SMN2HTR2C | |
| SCHEMBL4970307 | 0.77 | CNR1 (0.43) | SCD5RAB9ANPC1SMN1; SMN2HTR2C | |
| SCHEMBL4973533 | 0.77 | TRPC3 (0.39) | SCD5RAB9ANPC1SCDHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | claimed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | claimed |
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |