Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497318 | 0.87 | GPR119 (0.45) | POLB | |
| SCHEMBL497698 | 0.86 | HRH3 (0.63) | HRH3KCNH2CYP3A4CYP2C9POLB | |
| SCHEMBL28767928 | 0.82 | POLB (0.43) | CYP3A4CYP2C9POLB | |
| SCHEMBL29067319 | 0.79 | GPR119 (0.48) | MAPT | |
| SCHEMBL497161 | 0.79 | USP2 (0.46) | MAPTKDM4E | |
| SCHEMBL323889 | 0.79 | USP2 (0.46) | MAPTKDM4E | |
| SCHEMBL1438341 | 0.78 | ALDH1A1 (0.43) | POLB | |
| SCHEMBL503546 | 0.78 | NR1H2 (0.45) | MAPT | |
| SCHEMBL1993504 | 0.78 | RORC (0.49) | — | |
| SCHEMBL503531 | 0.78 | RORC (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106045-B2 | 2-morpholino-4-pyrimidone compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-01-31 | — | — | US | disclosed |