Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965737 | 0.90 | REN (0.36) | RENKDM4EALDH1A1F2 | |
| SCHEMBL4971676 | 0.88 | REN (0.37) | RENKDM4E | |
| SCHEMBL4972222 | 0.83 | REN (0.52) | REN | |
| SCHEMBL3968254 | 0.82 | REN (0.47) | REN | |
| SCHEMBL4973673 | 0.82 | REN (0.47) | REN | |
| SCHEMBL2327251 | 0.82 | REN (0.44) | RENALDH1A1 | |
| SCHEMBL2327255 | 0.82 | REN (0.44) | RENALDH1A1 | |
| SCHEMBL2327246 | 0.82 | REN (0.44) | RENALDH1A1 | |
| SCHEMBL4974117 | 0.80 | SLC6A2 (0.40) | REN | |
| SCHEMBL4969812 | 0.79 | REN (0.45) | RENKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |