SCHEMBL77023

SCHEMBL77023

COC(=O)/C(C#N)=C/N1c2ccccc2CC1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.44
ALDH1A1 P00352 5/20 0.41
KDM4E B2RXH2 4/20 0.41
TSHR P16473 2/20 0.41
GAA P10253 2/20 0.41
MAPT P10636 2/20 0.41
LMNA P02545 1/20 0.41
HPGD P15428 1/20 0.41
HSD17B10 Q99714 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
MCL1 Q07820 1/20 0.40
POLB P06746 2/20 0.39
PKM P14618 1/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
GFER P55789 1/20 0.38
MEN1 O00255 1/20 0.38
PLIN1 O60240 1/20 0.38
KMT2A Q03164 1/20 0.38
ABHD5 Q8WTS1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL77024 1.00 NOTUM (0.44) NOTUMALDH1A1KDM4ETSHRGAA
SCHEMBL7659901 0.87 ALDH1A1 (0.45) ALDH1A1KDM4EMAPTL3MBTL1POLB
SCHEMBL7659907 0.87 ALDH1A1 (0.45) ALDH1A1KDM4EMAPTL3MBTL1POLB
SCHEMBL7095410 0.83 NOTUM (0.44) NOTUMALDH1A1TSHRMAPTLMNA
SCHEMBL28809262 0.82 NOTUM (0.41) NOTUMALDH1A1KDM4ETSHRGAA
SCHEMBL7615113 0.82 LMNA (0.41) ALDH1A1LMNAPOLBSMN1; SMN2
SCHEMBL7615111 0.82 LMNA (0.41) ALDH1A1LMNAPOLBSMN1; SMN2
SCHEMBL11585384 0.82 PKM (0.42) NOTUMALDH1A1KDM4ETSHRGAA
SCHEMBL11587023 0.79 NOTUM (0.35) NOTUMALDH1A1KDM4ETSHRGAA
SCHEMBL29172566 0.78 NOTUM (0.48) NOTUMALDH1A1MAPTLMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3666 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120053283-A1 POLYMER ADDITIVES CONTAINING PARTICLES BASF SE (DE) 2012-03-01 US claimed
WO-2008083975-A1 LIGHT-STABILIZED COMPOSITION ISDIN S.A. (ES) 2008-07-17 WO claimed
EP-0142467-B1 POLYMER COMPOUNDS CONTAINING PIPERIDYL GROUPS AND THEIR USE AS STABILISERS IN SYNTHETIC POLYMERS CIBA-GEIGY S.p.A. (IT) 1988-08-24 EP claimed
US-6391949-B1 None US disclosed
US-12043719-B2 Flame retardant mixture CLARIANT INTERNATIONAL LTD (CH) 2024-07-23 US disclosed
WO-2024150714-A1 PROCESSING STABILIZER, RESIN COMPOSITION, AND ORGANIC MATERIAL STABILIZING METHOD 住友化学株式会社 2024-07-18 WO disclosed
US-20240218129-A1 BLOCK COPOLYMER POLYMER PROCESSING AIDS NOVA CHEMICALS (INTERNATIONAL) S.A. (CH) 2024-07-04 US disclosed
US-20240218160-A1 FLAME RETARDANT-STABILIZER COMBINATION FOR THERMOPLASTIC POLYMERS CLARIANT INTERNATIONAL LTD (CH) 2024-07-04 US disclosed
EP-4018870-B1 COMPONENTS OF ARTICLES OF FOOTWEAR, AND PROCESSES FOR MAKING ARTICLES OF FOOTWEAR OR COMPONENTS THEREOF NIKE INNOVATE CV (US) 2024-07-03 EP disclosed
US-20240199851-A1 Improved Polymer Composition CELANESE POLYMERS HOLDING, INC. 2024-06-20 US disclosed
US-20240200242-A1 KNIT TEXTILES AND UPPERS, AND PROCESSES FOR MAKING THE SAME NIKE, INC. 2024-06-20 US disclosed
EP-0081457-A2 Phenols and their uses as stabilizers CIBA-GEIGY AG (CH) 1983-06-15 EP disclosed
EP-0080431-A2 Synergistic mixture of low and high molecular weight polyalkyl piperidines CIBA-GEIGY AG (CH) 1983-06-01 EP disclosed
EP-0079855-A1 Alkylated hydroxyphenylthioalcanoic esters CIBA-GEIGY AG (CH) 1983-05-25 EP disclosed
US-4366280-A ELASTOMERS MODIFIED BY CALCIUM STEAROYL LACTATE OR DERIVATIVES; HEAT AND EXIDATION RESISTANCE K.K. MUSASHINO KAGAKU KENKYUSHO (JP) 1982-12-28 US disclosed
US-4325989-A ULTRAVIOLET RADIATION ABSORBER E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-04-20 US disclosed
US-4123418-A BIS-(U8I8I8L8L-PENTAMETHY TETRAMETHYL-4-PIPERIDYL)-SUBERATE CIBA-GEIGY CORPORATION (US) 1978-10-31 US disclosed
US-4110304-A STERICALLY HINDERED CYCLIC AMINE CIBA-GEIGY CORPORATION (US) 1978-08-29 US disclosed
US-4061631-A STABILIZER CIBA-GEIGY CORPORATION (US) 1977-12-06 US disclosed
US-3943098-A 1-Aza-4-thiacyclohexane-4,4-dioxide derivatives and their use as agents protecting against light rays CIBA-GEIGY CORPORATION (US) 1976-03-09 US disclosed