Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4974082 | 0.83 | TRPV4 (0.53) | MEN1KMT2ATRPV4 | |
| SCHEMBL5004460 | 0.77 | TRPV4 (0.53) | MAPTLMNAMEN1KMT2ATHRB | |
| SCHEMBL4971936 | 0.76 | TRPV4 (0.47) | MAPTMEN1KMT2ATRPV4 | |
| SCHEMBL13994327 | 0.74 | TRPV4 (0.52) | LMNAMEN1KMT2ATHRBTRPV4 | |
| SCHEMBL13994326 | 0.72 | TRPV4 (0.50) | MAPTLMNAMEN1KMT2ATRPV4 | |
| SCHEMBL5007940 | 0.71 | TRPV4 (0.52) | MEN1KMT2ATRPV4CCR1 | |
| SCHEMBL4771053 | 0.70 | CCR1 (0.39) | MEN1KMT2ATRPV4CCR1ATM | |
| SCHEMBL5007983 | 0.69 | CCR1 (0.39) | MEN1KMT2ATRPV4CCR1L3MBTL1 | |
| SCHEMBL7995044 | 0.68 | TRPV4 (0.41) | MAPTTRPV4CCR1 | |
| SCHEMBL4972298 | 0.67 | CHRM5 (0.34) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968590-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007070865-A2 | PIPERAZINE COMPOUNDS AS AGONISTS OF TRPV4 CHANNEL RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |