SCHEMBL4975651

SCHEMBL4975651

NC=CCc1cccc2c1C(=O)NC2=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 5/20 0.42
GSK3B P49841 3/20 0.39
CASP7 P55210 2/20 0.39
NPSR1 Q6W5P4 2/20 0.39
MEN1 O00255 2/20 0.39
POLB P06746 2/20 0.39
KMT2A Q03164 2/20 0.39
RGS12 O14924 1/20 0.39
USP2 O75604 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
MAPT P10636 1/20 0.39
THRB P10828 1/20 0.39
CYP2C9 P11712 1/20 0.39
APEX1 P27695 1/20 0.39
CASP1 P29466 1/20 0.39
BRCA1 P38398 1/20 0.39
MTOR P42345 1/20 0.39
RECQL P46063 1/20 0.39
BLM P54132 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16863190 0.90 PARP1 (0.47) PARP1GSK3BCASP7NPSR1MEN1
SCHEMBL10416488 0.84 PARP1 (0.42) PARP1GSK3BCASP7NPSR1MEN1
SCHEMBL11615870 0.84 KDM4E (0.42) PARP1GSK3BCASP7NPSR1MEN1
SCHEMBL2312958 0.84 PARP1 (0.42) PARP1GSK3BCASP7NPSR1MEN1
SCHEMBL7348724 0.83 PARP1 (0.41) PARP1GSK3BCASP7NPSR1MEN1
SCHEMBL709378 0.81 GSK3B (0.43) PARP1GSK3BCASP7NPSR1MEN1
SCHEMBL6347009 0.81 PARP1 (0.40) PARP1GSK3BCASP7NPSR1MEN1
SCHEMBL10879460 0.80 PARP1 (0.39) PARP1GSK3BCASP7NPSR1MEN1
SCHEMBL170914 0.80 GABRA1 (0.49) PARP1GSK3BCASP7NPSR1MEN1
Ammonia Solution, Strong SCHEMBL3259478 0.79 GABRA1 (0.47) PARP1GSK3BCASP7NPSR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1966335-A2 PIGMENT DISPERSIONS CONTAINING AMINATED ACRYLIC MACROMONOMER DISPERSANT E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-09-10 EP claimed
WO-2007070724-A2 PIGMENT DISPERSIONS CONTAINING AMINATED ACRYLIC MACROMONOMER DISPERSANT E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-06-21 WO claimed
US-5834579-A FOR PRODUCTION OF POLYURETHANE FOAM BACKED PLASTIC FILMS BAYER AKTIENGESELLSCHAFT (DE) 1998-11-10 US disclosed
EP-0696580-B1 Carbonate and urethane groups containing tertiary amines and their use as catalyst in the preparation of polyurethanes BAYER AG (DE) 1998-01-14 EP disclosed
US-5705672-A Tertiary amines having carbonate and urethane groups BAYER AKTIENGESELLSCHAFT (DE) 1998-01-06 US disclosed
EP-0696580-A2 Carbonate and urethane groups containing tertiary amines and their use as catalyst in the preparation of polyurethanes BAYER AG (DE) 1996-02-14 EP disclosed
EP-0369526-B1 Nitromethylene compounds, their preparation and their use as pesticides SHELL INT RESEARCH (NL) 1995-07-26 EP disclosed