Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28060232 | 0.75 | CHRM1 (0.45) | HSD17B10CHRM1ALDH1A1KMT2ATSHR | |
| SCHEMBL28737795 | 0.75 | CHRM1 (0.45) | HSD17B10CHRM1ALDH1A1KMT2ATSHR | |
| SCHEMBL4750370 | 0.75 | CHRM1 (0.45) | HSD17B10CHRM1ALDH1A1KMT2ATSHR | |
| SCHEMBL24308806 | 0.74 | HSD17B10 (0.52) | HSD17B10CHRM1ALDH1A1HTTTSHR | |
| SCHEMBL4752850 | 0.72 | CHRM1 (0.53) | HSD17B10CHRM1ALDH1A1KMT2ALMNA | |
| SCHEMBL28042762 | 0.72 | HSD11B1 (0.42) | ALDH1A1KMT2ATSHRMEN1POLB | |
| SCHEMBL2288262 | 0.70 | MDM2 (0.48) | HSD17B10KMT2AMEN1POLB | |
| SCHEMBL6478746 | 0.69 | TRPA1 (0.52) | — | |
| SCHEMBL6473879 | 0.69 | TRPA1 (0.52) | — | |
| SCHEMBL9421889 | 0.69 | TRPA1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |