Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4977531 | 1.00 | MCHR1 (0.63) | MCHR1SMN1; SMN2HTTPKMLMNA | |
| SCHEMBL5462606 | 0.80 | LMNA (0.64) | HTTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL5462612 | 0.80 | LMNA (0.64) | HTTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL6424778 | 0.77 | MCHR1 (1.00) | MCHR1SMN1; SMN2HTTPKMLMNA | |
| SCHEMBL10869289 | 0.77 | MAPK1 (0.73) | SMN1; SMN2HTTLMNAGAAALDH1A1 | |
| SCHEMBL6424782 | 0.77 | MCHR1 (1.00) | MCHR1SMN1; SMN2HTTPKMLMNA | |
| SCHEMBL5961390 | 0.77 | SIGMAR1 (0.75) | SMN1; SMN2LMNAGAAALDH1A1CHRM3 | |
| SCHEMBL13803755 | 0.77 | LMNA (0.84) | SMN1; SMN2HTTLMNAGAAALDH1A1 | |
| SCHEMBL7365408 | 0.76 | LMNA (0.68) | SMN1; SMN2HTTLMNAGAAALDH1A1 | |
| SCHEMBL7365405 | 0.76 | LMNA (0.68) | SMN1; SMN2HTTLMNAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | HRH3, HRH1, HRH4 | MCHR1 132/4885SMN1; SMN2 4046/4885HTT 499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.