Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2579539 | 0.91 | LMNA (0.72) | SIGMAR1ALDH1A1MAPK1LMNACYP3A4 | |
| SCHEMBL5462606 | 0.88 | LMNA (0.64) | SIGMAR1ALDH1A1MAPK1LMNAGAA | |
| SCHEMBL5462612 | 0.88 | LMNA (0.64) | SIGMAR1ALDH1A1MAPK1LMNAGAA | |
| SCHEMBL14045655 | 0.86 | ALDH1A1 (0.63) | SIGMAR1ALDH1A1MAPK1LMNACYP3A4 | |
| SCHEMBL8091680 | 0.86 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1MAPK1LMNACYP3A4 | |
| SCHEMBL8084551 | 0.86 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1MAPK1LMNACYP3A4 | |
| SCHEMBL27580427 | 0.86 | ALDH1A1 (0.63) | SIGMAR1ALDH1A1MAPK1LMNACYP3A4 | |
| SCHEMBL8084554 | 0.86 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1MAPK1LMNACYP3A4 | |
| SCHEMBL15759188 | 0.84 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1MAPK1LMNACYP3A4 | |
| SCHEMBL11036914 | 0.83 | LTA4H (0.77) | SIGMAR1ALDH1A1MAPK1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160312253-A1 | Compounds for Increasing Lipid Synthesis and Storage | INVITROGEN CORPORATION | 2016-10-27 | — | — | US | disclosed |
| US-20160158131-A1 | Compositions and Methods for Stimulating Collagen Synthesis in the Skin | AVON PRODUCTS, INC. (US) | 2016-06-09 | — | — | US | disclosed |
| US-9289365-B2 | Compositions and methods for stimulating collagen synthesis in the skin | AVON PRODUCTS, INC. (US) | 2016-03-22 | — | — | US | disclosed |
| US-9145410-B2 | Pyrazolopyridines and analogs thereof | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2015-09-29 | — | — | US | disclosed |
| US-9145410-B2 | Pyrazolopyridines and analogs thereof | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2015-09-29 | — | — | US | disclosed |
| US-20140081017-A1 | Histone Deacetylase Inhibitors for Enhancing Activity of Antifungal Agents | METHYLGENE INC. (CA) | 2014-03-20 | — | — | US | disclosed |
| WO-2013062667-A1 | COMPOSITIONS AND METHODS FOR STIMULATING COLLAGEN SYNTHESIS IN THE SKIN | AVON PRODUCTS, INC. (US) | 2013-05-02 | — | — | WO | disclosed |
| US-20130102606-A1 | Compositions and Methods for Stimulating Collagen Synthesis in the Skin | AVON PRODUCTS, INC. (US) | 2013-04-25 | — | — | US | disclosed |
| US-20120121651-A1 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | 3M INNOVATIVE PROPERTIES COMPANY | 2012-05-17 | — | — | US | disclosed |
| US-20120121651-A1 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | 3M INNOVATIVE PROPERTIES COMPANY | 2012-05-17 | — | — | US | disclosed |
| US-20070259881-A1 | Substituted Imidazo Ring Systems and Methods | COLEY PHARMACEUTICAL GROUP, INC. | 2007-11-08 | — | — | US | disclosed |
| EP-1492796-B1 | SUBSTITUTED AMINO ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS. | JANSSEN PHARMACEUTICA NV (BE) | 2007-09-05 | — | — | EP | disclosed |
| US-7265103-B2 | Substituted amino isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA NV. (BE) | 2007-09-04 | — | — | US | disclosed |
| US-7265103-B2 | Substituted amino isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA NV. (BE) | 2007-09-04 | — | — | US | disclosed |
| US-20070161641-A1 | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands | AVENTIS PHARMACEUTICALS INC. (US) | 2007-07-12 | — | — | US | disclosed |
| US-20070161641-A1 | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands | AVENTIS PHARMACEUTICALS INC. (US) | 2007-07-12 | — | — | US | disclosed |
| EP-1214292-B1 | TYROSINE DERIVATIVES | GENENTECH INC (US) | 2007-06-13 | — | — | EP | disclosed |
| US-7186724-B2 | Heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186724-B2 | Heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-06 | — | — | US | disclosed |
| WO-2005113003-A2 | METHOD FOR AUGMENTING B CELL DEPLETION | GENENTECH, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140081017-A1 | Histone Deacetylase Inhibitors for Enhancing Activity of Antifungal Agents | HDAC1, HDAC5, HDAC7 | SIGMAR1 4048/4885ALDH1A1 1728/4885MAPK1 1434/4885 |
| US-20160312253-A1 | Compounds for Increasing Lipid Synthesis and Storage | FASN, LIPC, SREBF2 | SIGMAR1 3599/4885ALDH1A1 1121/4885MAPK1 3804/4885 |
| US-20160158131-A1 | Compositions and Methods for Stimulating Collagen Synthesis in the Skin | COL14A1, COL2A1, COL1A1 | SIGMAR1 4651/4885ALDH1A1 3671/4885MAPK1 2138/4885 |
| US-20070259881-A1 | Substituted Imidazo Ring Systems and Methods | IL2, IL4, IRF3 | SIGMAR1 3081/4885ALDH1A1 2134/4885MAPK1 3282/4885 |
| US-20130102606-A1 | Compositions and Methods for Stimulating Collagen Synthesis in the Skin | COL14A1, COL2A1, COL1A1 | SIGMAR1 4651/4885ALDH1A1 3671/4885MAPK1 2138/4885 |
| US-20120121651-A1 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | IL4, IL4I1, IL2 | SIGMAR1 3328/4885ALDH1A1 1406/4885MAPK1 1387/4885 |
| US-20070161641-A1 | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands | DRD3, DRD2, HTR3C | SIGMAR1 55/4885ALDH1A1 904/4885MAPK1 3972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.