Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007940 | 0.85 | TRPV4 (0.52) | CCKBRMEN1KMT2AITGB1ITGA4 | |
| SCHEMBL22500389 | 0.78 | CCKBR (0.57) | CCKBRMEN1KMT2ACTSLCTSB | |
| SCHEMBL22500391 | 0.78 | CCKBR (0.57) | CCKBRMEN1KMT2ACTSLCTSB | |
| SCHEMBL13994327 | 0.74 | TRPV4 (0.52) | MEN1KMT2ALMNA | |
| SCHEMBL6565034 | 0.73 | NPC1 (0.66) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL4976334 | 0.73 | TRPV4 (0.68) | CCKBRITGB1ITGA4 | |
| SCHEMBL5004460 | 0.71 | TRPV4 (0.53) | MEN1KMT2ALMNA | |
| SCHEMBL5098654 | 0.70 | FPR2 (0.76) | MEN1KMT2ALMNAALDH1A1CTSL | |
| SCHEMBL5098656 | 0.70 | FPR2 (0.76) | MEN1KMT2ALMNAALDH1A1CTSL | |
| SCHEMBL22500340 | 0.69 | MEN1 (0.79) | MEN1KMT2AALDH1A1CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968590-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007070865-A2 | PIPERAZINE COMPOUNDS AS AGONISTS OF TRPV4 CHANNEL RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-21 | — | — | WO | claimed |