Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 18/20 | 0.87 |
| ▸ | RARG | P13631 | 17/20 | 0.87 |
| ▸ | RARA | P10276 | 16/20 | 0.87 |
| ▸ | RXRA | P19793 | 4/20 | 0.66 |
| ▸ | RXRB | P28702 | 1/20 | 0.53 |
| ▸ | RXRG | P48443 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL498293 | 0.86 | RARB (0.66) | RARBRARGRARARXRA | |
| SCHEMBL498280 | 0.83 | RARB (0.76) | RARBRARGRARARXRA | |
| SCHEMBL344900 | 0.83 | RARG (1.00) | RARBRARGRARARXRA | |
| SCHEMBL3677633 | 0.82 | RARB (0.76) | RARBRARGRARARXRARXRB | |
| SCHEMBL345684 | 0.82 | RARG (1.00) | RARBRARGRARARXRA | |
| SCHEMBL5846405 | 0.81 | RARG (0.98) | RARBRARGRARARXRA | |
| SCHEMBL5846253 | 0.81 | RARG (0.98) | RARBRARGRARARXRA | |
| SCHEMBL5845781 | 0.81 | RARG (0.98) | RARBRARGRARARXRA | |
| SCHEMBL5847036 | 0.81 | RARG (0.98) | RARBRARGRARARXRA | |
| SCHEMBL5845369 | 0.81 | RARG (0.98) | RARBRARGRARARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963249-B1 | BIPHENYL DERIVATIVES AS SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | GALDERMA RES & DEV (FR) | 2010-07-28 | — | — | EP | claimed |
| US-20090036536-A1 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-02-05 | — | — | US | claimed |
| US-20210355067-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | GALDERMA RESEARCH & DEVELOPEMENT (FR) | 2021-11-18 | — | — | US | disclosed |
| US-10995052-B2 | Biaromatic propynyl compounds, pharmaceutical and cosmetic compositions containing same, and uses thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2021-05-04 | — | — | US | disclosed |
| US-20190337881-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2019-11-07 | — | — | US | disclosed |
| US-10377694-B2 | Bi-aromatic propynyl compounds, pharmaceutical and cosmetic compositions containing them and uses thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2019-08-13 | — | — | US | disclosed |
| US-20180079707-A1 | NEW BI-AROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM AND USES THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-03-22 | — | — | US | disclosed |
| US-8106235-B2 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-01-31 | — | — | US | disclosed |
| US-8106235-B2 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-01-31 | — | — | US | disclosed |
| US-8106235-B2 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-01-31 | — | — | US | disclosed |
| EP-1963249-B1 | BIPHENYL DERIVATIVES AS SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | GALDERMA RES & DEV (FR) | 2010-07-28 | — | — | EP | disclosed |
| EP-1963249-B1 | BIPHENYL DERIVATIVES AS SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | GALDERMA RES & DEV (FR) | 2010-07-28 | — | — | EP | disclosed |
| US-20090036536-A1 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-02-05 | — | — | US | disclosed |
| US-20090036536-A1 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-02-05 | — | — | US | disclosed |
| US-20090036536-A1 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-02-05 | — | — | US | disclosed |
| EP-1963249-A1 | BIPHENYL DERIVATIVES AS SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | Galderma Research & Development (FR) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007068579-A1 | BIPHENYL DERIVATIVES AS SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-06-21 | — | — | WO | disclosed |
| WO-2007068579-A1 | BIPHENYL DERIVATIVES AS SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10995052-B2 | Biaromatic propynyl compounds, pharmaceutical and cosmetic compositions containing same, and uses thereof | TYR, MITF, PAOX | RARB 1278/4885RARG 909/4885RARA 974/4885 |
| US-20180079707-A1 | NEW BI-AROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM AND USES THEREOF | TYR, MITF, PAH | RARB 431/4885RARG 432/4885RARA 406/4885 |
| US-20210355067-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | MITF, TYR, PAOX | RARB 1410/4885RARG 1171/4885RARA 1162/4885 |
| US-10377694-B2 | Bi-aromatic propynyl compounds, pharmaceutical and cosmetic compositions containing them and uses thereof | TYR, MITF, PAH | RARB 510/4885RARG 506/4885RARA 477/4885 |
| US-20190337881-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | MITF, TYR, PAOX | RARB 1073/4885RARG 871/4885RARA 951/4885 |
| US-20090036536-A1 | Biphenyl compound selective agonists of gamma RAR receptors | RARG, RARB, RARA | RARB 2/4885RARG 1/4885RARA 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.