Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 14/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979261 | 0.85 | NOS3 (0.39) | NOS3NOS1NOS2 | |
| SCHEMBL1367775 | 0.70 | AR (0.36) | METAP2NOS3NOS1NOS2KCNA5 | |
| SCHEMBL4980354 | 0.69 | NOS3 (0.36) | NOS3NOS1NOS2KCNA5 | |
| SCHEMBL18464810 | 0.68 | DAO (0.43) | METAP2 | |
| SCHEMBL1370175 | 0.67 | GABRP (0.42) | NOS3NOS1NOS2KCNA5 | |
| SCHEMBL14992944 | 0.62 | METAP2 (0.46) | METAP2 | |
| SCHEMBL4175626 | 0.62 | MEN1 (0.62) | — | |
| SCHEMBL29695485 | 0.62 | MEN1 (0.62) | — | |
| SCHEMBL10146587 | 0.62 | METAP2 (0.46) | METAP2 | |
| SCHEMBL1367397 | 0.60 | NOS3 (0.35) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | claimed |