Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980340 | 0.85 | METAP2 (0.39) | NOS3NOS1NOS2 | |
| SCHEMBL4980354 | 0.73 | NOS3 (0.36) | NOS3NOS1NOS2PDK1PRKDC | |
| SCHEMBL1370175 | 0.71 | GABRP (0.42) | NOS3NOS1NOS2LMNAMAPT | |
| SCHEMBL1367495 | 0.68 | PRKDC (0.35) | NOS3NOS1NOS2PDE10APRKDC | |
| SCHEMBL1367397 | 0.66 | NOS3 (0.35) | NOS3NOS1NOS2PRKDC | |
| SCHEMBL1369269 | 0.64 | NOS2 (0.42) | NOS3NOS1NOS2MAOBPRKDC | |
| SCHEMBL1369018 | 0.63 | CYP17A1 (0.46) | — | |
| SCHEMBL1367302 | 0.63 | KCNA5 (0.64) | NOS3NOS1NOS2PRKDC | |
| SCHEMBL4312246 | 0.63 | DAO (0.50) | LMNAMAPTPGR | |
| SCHEMBL30176622 | 0.62 | KMT2A (0.55) | LMNAJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |