Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 10/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 9/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | CA4 | P22748 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4984827 | 0.92 | CA2 (0.44) | MEN1KMT2ACA2CA1CA12 | |
| SCHEMBL14964194 | 0.86 | SMN1; SMN2 (0.37) | MEN1KMT2AIDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14462765 | 0.84 | MEN1 (0.56) | MEN1KMT2ACA2SOS1CA1 | |
| SCHEMBL14964314 | 0.83 | CA2 (0.54) | MEN1KMT2ACA2SOS1CA1 | |
| SCHEMBL4979731 | 0.80 | IDO1 (0.34) | MEN1KMT2AIDO1HTTALDH1A1 | |
| SCHEMBL4971385 | 0.80 | ALDH1A1 (0.38) | MEN1KMT2AIDO1HTTTSHR | |
| SCHEMBL5632261 | 0.80 | MEN1 (0.55) | MEN1KMT2ACA2SOS1CA1 | |
| SCHEMBL5632268 | 0.80 | MEN1 (0.55) | MEN1KMT2ACA2SOS1CA1 | |
| SCHEMBL14964354 | 0.79 | ALDH1A1 (0.39) | MEN1KMT2AIDO1HTTALDH1A1 | |
| SCHEMBL14964279 | 0.79 | IDO1 (0.33) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |
| EP-1971583-A2 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | Incyte Corporation (US) | 2008-09-24 | — | — | EP | claimed |
| WO-2007075598-A2 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |