Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 11/20 | 0.54 |
| ▸ | CA12 | O43570 | 10/20 | 0.54 |
| ▸ | CA1 | P00915 | 10/20 | 0.54 |
| ▸ | CA9 | Q16790 | 9/20 | 0.54 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.43 |
| ▸ | CA7 | P43166 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985579 | 0.83 | MEN1 (0.45) | CA2CA12CA1CA9SOS1 | |
| SCHEMBL14980215 | 0.83 | CA2 (0.55) | CA2CA12CA1CA9SOS1 | |
| SCHEMBL14964289 | 0.82 | MAPT (0.38) | KMT2AMAOB | |
| SCHEMBL16581662 | 0.81 | MEN1 (0.34) | CA2CA12CA1CA9MEN1 | |
| SCHEMBL4984827 | 0.81 | CA2 (0.44) | CA2CA12CA1CA9MEN1 | |
| SCHEMBL16581976 | 0.80 | MAOB (0.36) | MEN1KMT2AMAOB | |
| SCHEMBL14964220 | 0.79 | SENP2 (0.37) | MEN1KMT2A | |
| SCHEMBL4976497 | 0.79 | CA2 (0.54) | CA2CA12CA1CA9SOS1 | |
| SCHEMBL4976505 | 0.79 | CA2 (0.54) | CA2CA12CA1CA9SOS1 | |
| SCHEMBL14964328 | 0.78 | IDO1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |