Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985292 | 0.96 | NPC1 (0.57) | MAPK1HSD17B10KDM4ELMNATSHR | |
| SCHEMBL4983022 | 0.90 | KDM4E (0.46) | MAPK1KDM4EALDH1A1HTTMEN1 | |
| SCHEMBL4986701 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL4984991 | 0.83 | KMT2A (0.43) | KDM4EALDH1A1HTTKMT2ACSF1R | |
| SCHEMBL4982960 | 0.81 | LIMK1 (0.61) | HSD17B10KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL4985030 | 0.81 | SIGMAR1 (0.50) | KDM4EALDH1A1MEN1KMT2ALIMK1 | |
| SCHEMBL13532653 | 0.79 | MAPK1 (0.47) | MAPK1HSD17B10KDM4ELMNATSHR | |
| SCHEMBL14272487 | 0.79 | NPC1 (0.46) | MAPK1HSD17B10KDM4ELMNATSHR | |
| SCHEMBL4982816 | 0.78 | BCHE (0.46) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL4985337 | 0.78 | DHFR (0.52) | SMN1; SMN2LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | MAPK1 546/4885HSD17B10 4009/4885KDM4E 4128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.