Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.57 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 2/20 | 0.54 |
| ▸ | CES1 | P23141 | 2/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18974747 | 0.86 | CES1 (0.59) | ALDH1A1MAPTHTTHSD17B10AGTR1 | |
| SCHEMBL18955583 | 0.85 | ALDH1A1 (0.66) | ALDH1A1MAPTHTTHSD17B10AGTR1 | |
| SCHEMBL27703398 | 0.85 | ALDH1A1 (0.72) | ALDH1A1MAPTHSD17B10AGTR1KMT2A | |
| SCHEMBL6317939 | 0.83 | ALDH1A1 (0.54) | ALDH1A1MAPTHTTHSD17B10AGTR1 | |
| SCHEMBL6317943 | 0.83 | ALDH1A1 (0.54) | ALDH1A1MAPTHTTHSD17B10AGTR1 | |
| SCHEMBL18974294 | 0.83 | ALDH1A1 (0.62) | ALDH1A1MAPTHTTHSD17B10AGTR1 | |
| SCHEMBL11453331 | 0.83 | ALDH1A1 (0.77) | ALDH1A1MAPTHTTHSD17B10KMT2A | |
| SCHEMBL7091522 | 0.81 | ALDH1A1 (0.67) | ALDH1A1MAPTHSD17B10AGTR1KMT2A | |
| SCHEMBL18974291 | 0.81 | ALDH1A1 (1.00) | ALDH1A1MAPTHSD17B10AGTR1KMT2A | |
| SCHEMBL10430383 | 0.81 | ALDH1A1 (0.64) | ALDH1A1MAPTHTTHSD17B10AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017099695-A1 | N-[(AMINOSULFONYL)PHENYL]-2-(1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)-HYDRAZINECARBOTHIOAMIDE DERIVATIVES FOR TREATING CANCER AND IMMUNOLOGICAL DISORDERS | ISTANBUL UNIVERSITESI REKTORLUGU (TR) | 2017-06-15 | — | — | WO | disclosed |
| CN-103271906-A | Use of spiro-oxindole compounds as therapeutic agents | XENON PHARMACEUTICALS INC | 2013-09-04 | — | — | CN | disclosed |
| CN-102153562-A | Spiro-oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC | 2011-08-17 | — | — | CN | disclosed |
| CN-101631546-A | Use of spiro-indolone compounds as therapeutic agents | XENON PHARMACEUTICALS INC | 2010-01-20 | — | — | CN | disclosed |
| CN-101213174-A | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-07-02 | — | — | CN | disclosed |
| US-20080125469-A1 | Thiadiazole compounds and methods of use thereof | WYETH (US) | 2008-05-29 | — | — | US | disclosed |
| CN-101184761-A | Spiro-indolone compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-05-21 | — | — | CN | disclosed |
| WO-2007132280-A1 | ISATIN AND ITS DERIVATIVES FOR USE AS A MEDICAMENT | Szegedi Tudományegyetem (HU) | 2007-11-22 | — | — | WO | disclosed |
| EP-0432648-B1 | Isatine derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-08-02 | — | — | EP | disclosed |
| US-5198461-A | Isatine derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-03-30 | — | — | US | disclosed |
| US-5192792-A | Isatine derivatives, and their method of use | WARNER-LAMBERT COMPANY (US) | 1993-03-09 | — | — | US | disclosed |
| US-5164404-A | HYDRAZONE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S (DK) | 1992-11-17 | — | — | US | disclosed |
| EP-0503349-A1 | Hydrazone derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1992-09-16 | — | — | EP | disclosed |
| US-5093364-A | 5-FLUOROANTHRANILIC FUNGICIDES | SCHERING AGROCHEMICALS LIMITED (GB) | 1992-03-03 | — | — | US | disclosed |
| EP-0432648-A2 | Isatine derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1991-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125469-A1 | Thiadiazole compounds and methods of use thereof | ADAMTS5, ADAMTS1, TIMP3 | ALDH1A1 388/4885MAPT 1320/4885HTT 2651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.