Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982816 | 0.82 | BCHE (0.46) | LIMK1DHFRALDH1A1KDM4EMEN1 | |
| SCHEMBL4982960 | 0.82 | LIMK1 (0.61) | LIMK1DHFRALDH1A1KDM4EMEN1 | |
| SCHEMBL4992461 | 0.80 | LIMK1 (0.47) | LIMK1DHFRALDH1A1KDM4EMEN1 | |
| SCHEMBL4988140 | 0.79 | PDE2A (0.40) | LIMK1DHFRTSHRGRM2 | |
| SCHEMBL4988567 | 0.79 | MEN1 (0.52) | LIMK1MEN1KMT2A | |
| SCHEMBL4986172 | 0.78 | SMN1; SMN2 (0.47) | LIMK1DHFRATMKDM4EMEN1 | |
| SCHEMBL4992058 | 0.78 | PDE2A (0.41) | LIMK1DHFRALDH1A1L3MBTL1LMNA | |
| SCHEMBL4984972 | 0.78 | RAB9A (0.38) | ALDH1A1KDM4ELMNA | |
| SCHEMBL4989327 | 0.78 | BCHE (0.53) | DHFRALDH1A1TSHRL3MBTL1KDM4E | |
| SCHEMBL4988053 | 0.77 | ALDH1A1 (0.58) | LIMK1DHFRALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | LIMK1 1960/4885CYP2A13 1411/4885DHFR 4248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.