Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980900 | 0.86 | P2RX3 (0.39) | DPP4DPP8DPP7P2RX3P2RX7 | |
| SCHEMBL4985073 | 0.83 | PTGDR2 (0.37) | P2RX7 | |
| SCHEMBL4984698 | 0.80 | F12 (0.42) | P2RX7 | |
| SCHEMBL4991248 | 0.78 | GNRHR (0.36) | — | |
| SCHEMBL4988247 | 0.77 | RIPK1 (0.40) | P2RX7 | |
| SCHEMBL14272287 | 0.77 | TSHR (0.52) | — | |
| SCHEMBL4988613 | 0.76 | CGAS (0.40) | P2RX7 | |
| SCHEMBL4990995 | 0.75 | MAP4K4 (0.41) | P2RX7 | |
| SCHEMBL4990641 | 0.75 | ALDH1A1 (0.39) | P2RX7 | |
| SCHEMBL19959250 | 0.74 | ADORA1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | DPP4 1987/4885DPP8 1805/4885DPP7 2026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.