Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3266092 | 0.66 | KDM4E (0.32) | GABRA1GABRB2 | |
| SCHEMBL28755286 | 0.64 | ALDH1A1 (0.36) | GABRA1GABRB2NR4A3 | |
| SCHEMBL29920871 | 0.64 | MEN1 (0.33) | GABRA1GABRB2 | |
| SCHEMBL1662619 | 0.64 | PARP1 (0.39) | PARP1 | |
| SCHEMBL11400414 | 0.63 | DRD3 (0.33) | — | |
| SCHEMBL27651230 | 0.60 | — | — | |
| Acetamide SCHEMBL27416699 | 0.60 | GABRA1 (0.50) | PARP1GABRA1GABRB2 | |
| SCHEMBL3649822 | 0.57 | NOTUM (0.66) | PARP1 | |
| SCHEMBL162640 | 0.57 | — | — | |
| SCHEMBL28291320 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417047-B2 | Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation | WYETH (US) | 2008-08-26 | — | — | US | claimed |