Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2129323 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MAPK1SMN1; SMN2TAAR1MEN1 | |
| SCHEMBL9704535 | 0.84 | POLB (0.51) | ALDH1A1MAPK1SMN1; SMN2TAAR1MEN1 | |
| SCHEMBL2129585 | 0.83 | ALDH1A1 (0.49) | ALDH1A1MAPK1SMN1; SMN2TAAR1MEN1 | |
| SCHEMBL473877 | 0.80 | ALDH1A1 (0.74) | ALDH1A1MAPK1SMN1; SMN2TAAR1MEN1 | |
| SCHEMBL29384281 | 0.80 | ALDH1A1 (0.74) | ALDH1A1MAPK1SMN1; SMN2TAAR1MEN1 | |
| SCHEMBL894222 | 0.76 | ALDH1A1 (0.57) | ALDH1A1MAPK1SMN1; SMN2TAAR1MEN1 | |
| SCHEMBL29982859 | 0.76 | ALDH1A1 (0.57) | ALDH1A1MAPK1SMN1; SMN2TAAR1MEN1 | |
| SCHEMBL9589529 | 0.75 | SMN1; SMN2 (0.55) | ALDH1A1MAPK1SMN1; SMN2TAAR1MEN1 | |
| SCHEMBL27691281 | 0.74 | TDP1 (0.41) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11001556 | 0.74 | SMN1; SMN2 (0.34) | ALDH1A1MAPK1SMN1; SMN2TAAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171732-A1 | New Pyridine Analogues IX 519 | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171732-A1 | New Pyridine Analogues IX 519 | P2RY12, P2RY11, P2RY1 | ALDH1A1 1518/4885MAPK1 979/4885SMN1; SMN2 3568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.