Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473877 | 0.81 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 | |
| SCHEMBL29982859 | 0.81 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 | |
| SCHEMBL894222 | 0.81 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 | |
| SCHEMBL29384281 | 0.81 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 | |
| SCHEMBL8606559 | 0.79 | AKR1C2 (0.48) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 | |
| SCHEMBL3753379 | 0.78 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 | |
| SCHEMBL19991225 | 0.78 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 | |
| SCHEMBL12563879 | 0.78 | MAPK1 (0.53) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 | |
| SCHEMBL3407348 | 0.78 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 | |
| SCHEMBL535587 | 0.78 | KEAP1 (0.48) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |
| US-5262387-A | Pyridine derivatives and their use for controlling undesirable plant growth | BASF AKTIENGESELLSCHAFT (DE) | 1993-11-16 | — | — | US | disclosed |
| US-5262384-A | Herbicides | BASF AKTIENGESELLSCHAFT (DE) | 1993-11-16 | — | — | US | disclosed |