Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 5/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163523 | 0.79 | ALDH1A1 (0.54) | PIK3R1PIK3CAMEN1KMT2AHSD17B10 | |
| SCHEMBL28202407 | 0.78 | PIK3R1 (0.56) | PIK3R1PIK3CAMEN1KMT2APTGS1 | |
| SCHEMBL5000806 | 0.77 | PIK3R1 (0.38) | PIK3R1PIK3CAMEN1KMT2AHSD17B10 | |
| SCHEMBL5000809 | 0.76 | FYN (0.52) | MEN1KMT2AHSD17B10MAPTALDH1A1 | |
| SCHEMBL13930938 | 0.72 | RAB9A (0.58) | PIK3R1PIK3CAMEN1KMT2AHSD17B10 | |
| SCHEMBL3251579 | 0.71 | PIK3R1 (0.48) | PIK3R1PIK3CAMEN1KMT2AHSD17B10 | |
| SCHEMBL13261826 | 0.70 | KMO (0.51) | MEN1KMT2AKMOL3MBTL1NPC1 | |
| SCHEMBL3263388 | 0.69 | PIK3R1 (0.49) | PIK3R1PIK3CAMEN1KMT2AHSD17B10 | |
| SCHEMBL3533444 | 0.68 | PDE10A (0.46) | MEN1KMT2AHSD17B10MAPTALDH1A1 | |
| SCHEMBL3063935 | 0.68 | MAPT (0.53) | MEN1KMT2APTGS1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | PIK3R1 3081/4885PIK3CA 2921/4885MEN1 1557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.