Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4983021 | 0.88 | SIGMAR1 (0.50) | ABCB1ABCC1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL4983752 | 0.86 | HTT (0.52) | SMN1; SMN2ABCB1ABCC1HPGDHSD17B10 | |
| SCHEMBL4986049 | 0.85 | POLB (0.45) | SMN1; SMN2MAPTL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL4989360 | 0.85 | NPC1 (0.46) | L3MBTL1ALDH1A1GAAKMT2ARAB9A | |
| SCHEMBL4988726 | 0.85 | P2RX3 (0.46) | ABCB1ABCC1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL4989547 | 0.83 | HPGD (0.49) | HPGDL3MBTL1ALDH1A1GAAKMT2A | |
| SCHEMBL4988613 | 0.80 | CGAS (0.40) | SMN1; SMN2HPGDHSD17B10ALDH1A1KMT2A | |
| SCHEMBL4984698 | 0.79 | F12 (0.42) | RAB9ANPC1 | |
| SCHEMBL4985337 | 0.78 | DHFR (0.52) | SMN1; SMN2ABCB1ABCC1SIGMAR1 | |
| SCHEMBL14272275 | 0.78 | TSHR (0.52) | SMN1; SMN2ABCB1ABCC1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | SMN1; SMN2 4369/4885ABCB1 141/4885ABCC1 1268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.