Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4991818 | 1.00 | HTR3E (0.39) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL5002581 | 0.79 | HTR3A (0.36) | HTR3AIDO1TDO2 | |
| SCHEMBL5002582 | 0.79 | HTR3A (0.36) | HTR3AIDO1TDO2 | |
| SCHEMBL4996837 | 0.73 | HTR3A (0.39) | HTR3A | |
| SCHEMBL4996842 | 0.73 | HTR3A (0.39) | HTR3A | |
| SCHEMBL4985663 | 0.73 | CHRNA7 (0.40) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL4985660 | 0.73 | CHRNA7 (0.40) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL15441397 | 0.69 | CHRNB2 (0.58) | CHRNA7HTR3A | |
| SCHEMBL15441398 | 0.69 | CHRNB2 (0.58) | CHRNA7HTR3A | |
| SCHEMBL13734805 | 0.66 | CHRNB2 (0.67) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188518-A1 | 5-Substituted Imidazoles | ASTRA ZENECA AB (SE) | 2008-08-07 | — | — | US | disclosed |
| US-20080188518-A1 | 5-Substituted Imidazoles | ASTRA ZENECA AB (SE) | 2008-08-07 | — | — | US | disclosed |
| US-20080188518-A1 | 5-Substituted Imidazoles | ASTRA ZENECA AB (SE) | 2008-08-07 | — | — | US | disclosed |
| EP-1687302-A1 | 5-SUBSTITUTED IMIDAZOLES | AstraZeneca AB (SE) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005049611-A1 | 5-SUBSTITUTED IMIDAZOLES | ASTRAZENECA AB (SE) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188518-A1 | 5-Substituted Imidazoles | GABRA5, GRIN2C, GABRE | HTR3E 534/4885HTR3B 778/4885CHRNA7 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.