Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5695494 | 0.90 | OPRM1 (0.36) | OPRM1OPRL1 | |
| SCHEMBL4685647 | 0.76 | OPRM1 (0.33) | DPP4AKR1C1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6472118 | 0.75 | AKR1C1 (0.38) | DPP4AKR1C1SLC6A4OPRM1 | |
| SCHEMBL4984844 | 0.71 | SLC6A4 (0.38) | DPP4AKR1C1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL29456941 | 0.69 | MAOB (0.44) | SLC6A4 | |
| SCHEMBL2913180 | 0.69 | AKR1C1 (0.41) | AKR1C1 | |
| SCHEMBL4540372 | 0.67 | OPRL1 (0.39) | DPP4SLC6A4OPRM1OPRL1 | |
| SCHEMBL9330358 | 0.65 | DPP4 (0.63) | DPP4SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3518757 | 0.65 | SLC6A3 (0.42) | AKR1C1SLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL5853830 | 0.64 | SLC6A4 (0.63) | DPP4SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227850-A1 | USE OF NOREPINEPHRINE REUPTAKE MODULATORS FOR PREVENTING AND TREATING VASOMOTOR SYMPTOMS | WYETH (US) | 2008-09-18 | — | — | US | disclosed |
| US-7345096-B2 | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms | WYETH (US) | 2008-03-18 | — | — | US | disclosed |
| EP-1551380-A1 | A METHOD OF TREATING VASOMOTOR SYMPTOMS COMPRISING A COMPOUND HAVING NOREPINEPHRINE REUPTAKE INHIBITOR ACTIVITY AND 5-HT2A ANTAGONISTIC ACTIVITY | Wyeth (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004035036-A1 | A METHOD OF TREATING VASOMOTOR SYMPTOMS COMPRISING A COMPOUND HAVING NOREPINEPHRINE REUPTAKE INHIBITOR ACTIVITY AND 5-HT2A ANTAGONISTIC ACTIVITY | WYETH (US) | 2004-04-29 | — | — | WO | disclosed |