Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL518236 | 0.83 | AKR1C1 (0.40) | AKR1C1OPRM1PRCPSIGMAR1DPP4 | |
| SCHEMBL6470519 | 0.79 | TACR1 (0.35) | AKR1C1OPRM1TACR1PRCPSIGMAR1 | |
| SCHEMBL11325518 | 0.78 | OPRM1 (0.41) | AKR1C1OPRM1PRCPSIGMAR1DPP4 | |
| SCHEMBL2913180 | 0.78 | AKR1C1 (0.41) | AKR1C1HDAC4SMN1; SMN2 | |
| SCHEMBL5538611 | 0.75 | AKR1C1 (0.38) | AKR1C1OPRM1PRCPSIGMAR1DPP4 | |
| SCHEMBL4991848 | 0.75 | TRPA1 (0.36) | AKR1C1OPRM1DPP4SLC6A4 | |
| Hydrochloric Acid SCHEMBL6926723 | 0.74 | ALDH1A1 (0.39) | AKR1C1OPRM1PRCPSIGMAR1OPRD1 | |
| SCHEMBL2432531 | 0.73 | TSHR (0.42) | AKR1C1OPRM1SLC18A3PRCPSIGMAR1 | |
| SCHEMBL2432100 | 0.72 | TSHR (0.44) | OPRM1PRCPSIGMAR1OPRD1ALDH1A1 | |
| SCHEMBL5695494 | 0.68 | OPRM1 (0.36) | OPRM1SLC18A3OPRD1OPRK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | AKR1C1 3957/4885OPRM1 39/4885SLC18A3 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.