Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | COMT | P21964 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996644 | 0.80 | CFTR (0.37) | SOS1ALDH1A1TSHRHPGDMEN1 | |
| SCHEMBL5004221 | 0.78 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1TSHRTDP1PKM | |
| SCHEMBL3016189 | 0.70 | TDP1 (0.35) | SMN1; SMN2ALDH1A1TSHRTDP1HPGD | |
| SCHEMBL7009698 | 0.70 | PDGFRB (0.41) | SMN1; SMN2SOS1ALDH1A1PKMPDGFRB | |
| SCHEMBL2437573 | 0.69 | AR (0.35) | SMN1; SMN2ALDH1A1TSHRTDP1NPSR1 | |
| SCHEMBL3036535 | 0.67 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1TSHRTDP1PKM | |
| SCHEMBL11512029 | 0.67 | PDGFRB (0.49) | SMN1; SMN2ALDH1A1TSHRTDP1PDGFRB | |
| SCHEMBL27816651 | 0.66 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1TSHRTDP1PKM | |
| SCHEMBL28418045 | 0.65 | SOS1 (0.44) | SMN1; SMN2SOS1ALDH1A1TDP1PKM | |
| SCHEMBL2522809 | 0.65 | PDGFRB (0.50) | SMN1; SMN2ALDH1A1TDP1PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | SPTLC1, SPTLC2, CPT1A | SMN1; SMN2 1145/4885SOS1 962/4885ALDH1A1 2622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.