SCHEMBL4997675

SCHEMBL4997675

Nc1cc(F)c2c(c1)CC(=O)N2CCF

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ATAD2 Q6PL18 1/20 0.31
PER2 O15055 1/20 0.31
CRY2 Q49AN0 1/20 0.31
KDM4E B2RXH2 1/20 0.30
RXRA P19793 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5001377 0.86 CYP19A1 (0.38) ATAD2
SCHEMBL5505340 0.85 CYP19A1 (0.37) ATAD2
SCHEMBL4997606 0.83 ATAD2 (0.44) ATAD2
SCHEMBL5004922 0.79 MEN1 (0.34) ATAD2
SCHEMBL5004930 0.77 BMPR1B (0.42) ATAD2
SCHEMBL4992293 0.76 CHRM1 (0.38) PER2CRY2
SCHEMBL5511206 0.76 BMPR1B (0.41) ATAD2
SCHEMBL5116891 0.75 ATAD2 (0.50) ATAD2PER2CRY2
SCHEMBL4997031 0.74 F10 (0.43)
SCHEMBL4997023 0.74 F10 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080262056-A1 Oxindole Oxazolidinones as Antibacterial Agents PFIZER INC 2008-10-23 US disclosed
US-7435751-B2 7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents JOSYULA VARA PRASAD VENKATA NAGENDRA 2008-10-14 US disclosed
US-20060229349-A1 7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents JOSYULA VARA PRASAD V N 2006-10-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229349-A1 7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents OXA1L, MRPL21, FOXM1 ATAD2 2084/4885PER2 4578/4885CRY2 4031/4885
US-20080262056-A1 Oxindole Oxazolidinones as Antibacterial Agents OXA1L, OXSR1, OXER1 ATAD2 1891/4885PER2 4278/4885CRY2 2957/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.