Sugi Predict

Sugi Predict / Compounds / Formamide

Formamide

Formamide

SCHEMBL4997873

Cc1cccn1C.NC=O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRIM24 O15164 1/20 0.50
▸ TRIM33 Q9UPN9 1/20 0.50
▸ TSHR P16473 1/20 0.40
▸ ALDH1A1 P00352 6/20 0.36
▸ KDM4E B2RXH2 3/20 0.36
▸ MAPT P10636 4/20 0.34
▸ USP2 O75604 3/20 0.34
▸ KMT2A Q03164 3/20 0.34
▸ GAA P10253 3/20 0.34
▸ SMN1; SMN2 Q16637 3/20 0.34
▸ NPC1 O15118 2/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ TLR9 Q9NR96 2/20 0.34
▸ TDP1 Q9NUW8 2/20 0.34
▸ NFKB1 P19838 1/20 0.34
▸ NFKB2 Q00653 1/20 0.34
▸ RELA Q04206 1/20 0.34
▸ CYP2C9 P11712 1/20 0.33
▸ LMNA P02545 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL143814 0.85 — —
SCHEMBL8676817 0.83 — —
SCHEMBL4282205 0.83 — —
Fluoride SCHEMBL30212653 0.83 — —
Ammonia Solution, Strong SCHEMBL27847806 0.83 — —
Dimethylamine SCHEMBL385867 0.78 TSHR (0.39) TRIM24TRIM33TSHRALDH1A1KDM4E
Acetic Acid SCHEMBL687743 0.77 RAB9A (0.41) TRIM24TRIM33TSHRALDH1A1KDM4E
Ethoxycarbonyl Group SCHEMBL28063745 0.77 TRIM24 (0.41) TRIM24TRIM33TSHRALDH1A1KDM4E
Diethylamine SCHEMBL3973793 0.76 TRIM24 (0.39) TRIM24TRIM33TSHRALDH1A1KDM4E
SCHEMBL25469300 0.71 TSHR (0.43) TRIM24TRIM33TSHRALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114599653-A Indazoles as inhibitors of hematopoietic progenitor kinase 1(HPK1) and methods of use thereof 第一生物治疗股份有限公司 2022-06-07 — — CN claimed
CN-103502241-A Substituted pyrimidinyl-pyrroles active as kinase inhibitors NERVIANO MEDICAL SCIENCES SRL 2014-01-08 — — CN claimed
US-7417047-B2 Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation WYETH (US) 2008-08-26 — — US claimed
CN-103502241-B As the pyrimidinyl-pyrrolesactive active of the replacement of kinase inhibitor NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2016-03-23 — — CN disclosed
US-20160046576-A1 NOVEL PYRROLE DERIVATIVES UNIV LEICESTER (GB) 2016-02-18 — — US disclosed
CN-103502241-A Substituted pyrimidinyl-pyrroles active as kinase inhibitors NERVIANO MEDICAL SCIENCES SRL 2014-01-08 — — CN disclosed
CN-103261196-A Pyrazolopyridines as inhibitors of the kinase lrrk2 MEDICAL RES COUNCIL TECHNOLOGY 2013-08-21 — — CN disclosed
CN-102686577-A Compounds as tyrosine kinase modulators ALLERGAN INC 2012-09-19 — — CN disclosed
CN-1805930-A Hydroxamic acids useful in the treatment of hyper-proliferative disorders BAYER PHARMACEUTICALS CORP (US) 2006-07-19 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160046576-A1 NOVEL PYRROLE DERIVATIVES PYCR1, ARG1, PNISR TRIM24 3773/4885TRIM33 2437/4885TSHR 598/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.