Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420965 | 0.79 | KDM4E (0.38) | KDM4EALDH1A1POLBMAPTGAA | |
| SCHEMBL5002884 | 0.72 | KDM4E (0.33) | KDM4EALDH1A1POLB | |
| SCHEMBL1378162 | 0.69 | LAP3 (0.31) | — | |
| SCHEMBL5002524 | 0.68 | TSHR (0.39) | KDM4EALDH1A1POLBHSD17B10GAA | |
| SCHEMBL13805269 | 0.68 | TSHR (0.39) | KDM4EALDH1A1POLBHSD17B10GAA | |
| SCHEMBL776263 | 0.67 | LAP3 (0.36) | ALDH1A1 | |
| SCHEMBL2382813 | 0.66 | AOX1 (0.33) | ALDH1A1 | |
| SCHEMBL1251447 | 0.66 | PPARD (0.35) | — | |
| SCHEMBL11745106 | 0.66 | LAP3 (0.34) | ALDH1A1 | |
| SCHEMBL4574776 | 0.64 | LAP3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312430-A1 | Method of Preparing or Synthesizing Polyazamacrocycle Derivatives | THERAPHARM GMBH (CH) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312430-A1 | Method of Preparing or Synthesizing Polyazamacrocycle Derivatives | POLI, PARP1, DHPS | KDM4E 2936/4885ALDH1A1 2631/4885POLB 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.