Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CES2 | O00748 | 3/20 | 0.47 |
| ▸ | CES1 | P23141 | 3/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | PRKCA | P17252 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21693932 | 0.98 | CES2 (0.49) | LMNACES2CES1NAAATDP1 | |
| SCHEMBL4189905 | 0.88 | LMNA (0.55) | LMNACES2CES1TDP1TSHR | |
| SCHEMBL6551288 | 0.84 | LMNA (0.47) | LMNACES2CES1TDP1TSHR | |
| SCHEMBL22439055 | 0.83 | SOAT2 (0.49) | LMNACES2CES1NAAATDP1 | |
| SCHEMBL21528269 | 0.83 | SOAT2 (0.49) | LMNACES2CES1NAAATDP1 | |
| SCHEMBL6552841 | 0.83 | SOAT2 (0.49) | LMNACES2CES1NAAATDP1 | |
| SCHEMBL6552638 | 0.83 | SOAT2 (0.49) | LMNACES2CES1NAAATDP1 | |
| SCHEMBL6552826 | 0.83 | SOAT2 (0.49) | LMNACES2CES1NAAATDP1 | |
| SCHEMBL6552788 | 0.83 | SOAT2 (0.49) | LMNACES2CES1NAAATDP1 | |
| SCHEMBL6552573 | 0.83 | SOAT2 (0.49) | LMNACES2CES1NAAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111385-B1 | Substituted alkine derivatives as anti-cancer agents | UNIV LOUISVILLE RES FOUND (US) | 2014-11-12 | — | — | EP | disclosed |
| US-8703829-B2 | Therapeutic compounds | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| EP-2567950-A1 | Substituted alkine derivatives as anti-cancer agents | University Of Louisville Research Foundation, Inc. (US) | 2013-03-13 | — | — | EP | disclosed |
| US-20120329866-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION (US) | 2012-12-27 | — | — | US | disclosed |
| US-8207381-B2 | 1-Bromo-1,1-difluoro-non-2-yn-4-ol; 6-Bromo-6,6-difluoro-2,2-dimethyl-hex-4-yn-3-ol; anticarcinogenic, -tumor, -metastasic agents; enzyme inhibitors of modification methylases; myelodysplastic syndrome, leukemia, a solid tumor, schizophrenia, sickle cell disease, or lupus; breast, colon, brain cancers | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION (US) | 2012-06-26 | — | — | US | disclosed |
| US-20080188570-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION | 2008-08-07 | — | — | US | disclosed |
| US-4496447-A | PHOTOPOLYMERIZATION OF UNSATURATED COMPOUNDS AND FOR CURING PRINTING INKS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1985-01-29 | — | — | US | disclosed |
| US-4374984-A | Aromatic-aliphatic ketones useful as photoinitiators | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188570-A1 | THERAPEUTIC COMPOUNDS | ABCB1, NQO1, ABCB11 | LMNA 1586/4885CES2 100/4885CES1 445/4885 |
| US-20120329866-A1 | THERAPEUTIC COMPOUNDS | ABCB1, MCL1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | LMNA 1925/4885CES2 73/4885CES1 620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.