Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PPARD | Q03181 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4924469 | 0.91 | DGKA (0.38) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL26968050 | 0.91 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL5606592 | 0.91 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL30480643 | 0.91 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL29351742 | 0.91 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL25353913 | 0.91 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL28126894 | 0.91 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL1642803 | 0.91 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL27467023 | 0.89 | TSHR (0.60) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL1668338 | 0.89 | LMNA (0.61) | TSHRLMNANFKB1PMP22GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275005-A1 | MITOCHONDRIALLY TARGETED ANTIOXIDANTS | ANTIPODEAN PHARMACEUTICALS, INC. | 2008-11-06 | — | — | US | disclosed |
| US-20070270381-A1 | Mitochondrially targeted antioxidants | ANTIPODEAN PHARMACEUTICALS, INC. (US) | 2007-11-22 | — | — | US | disclosed |
| US-7232809-B2 | Mitochondrially targeted antioxidants | ANTIPODEAN PHARMACEUTICALS, INC. (US) | 2007-06-19 | — | — | US | disclosed |
| US-20050245487-A1 | Mitochondrially targeted antioxidants | ANTIPODEAN BIOTECHNOLOGY LIMITED (NZ) | 2005-11-03 | — | — | US | disclosed |
| US-20040106579-A1 | Mitochondrially targeted antioxidants | UNIVERSITY OF OTAGO (NZ) | 2004-06-03 | — | — | US | disclosed |
| US-20030069208-A1 | Mitochondrially targeted antioxidants | UNIVERSITY OF OTAGO | 2003-04-10 | — | — | US | disclosed |
| US-20020052342-A1 | Mitochondrially targeted antioxidants | UNIVERSITY OF OTAGO | 2002-05-02 | — | — | US | disclosed |
| US-6331532-B1 | COMPOUND COMPRISING LIPOPHILIC CATION COVALENTLY COUPLED TO ANTIOXIDANT MOIETY WHICH IS CAPABLE OF BEING TRANSPORTED THROUGH MITOCHONDRIAL MEMBRANE AND ACCUMULATED WITHIN MITOCHONDRIA OF INTACT CELLS | UNIVERSITY OF OTAGO (NZ) | 2001-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245487-A1 | Mitochondrially targeted antioxidants | PRDX5, TXN2, TXNRD2 | TSHR 3829/4885LMNA 1201/4885NFKB1 1594/4885 |
| US-20030069208-A1 | Mitochondrially targeted antioxidants | PRDX5, TXNRD2, TXN2 | TSHR 4254/4885LMNA 1167/4885NFKB1 1119/4885 |
| US-20070270381-A1 | Mitochondrially targeted antioxidants | PRDX5, TXN2, PRDX3 | TSHR 3778/4885LMNA 1154/4885NFKB1 1773/4885 |
| US-20020052342-A1 | Mitochondrially targeted antioxidants | PRDX5, PRDX3, TXN2 | TSHR 3805/4885LMNA 960/4885NFKB1 1341/4885 |
| US-20080275005-A1 | MITOCHONDRIALLY TARGETED ANTIOXIDANTS | PRDX5, TXN2, PRDX3 | TSHR 3778/4885LMNA 1154/4885NFKB1 1773/4885 |
| US-20040106579-A1 | Mitochondrially targeted antioxidants | PRDX5, PRDX3, TXN2 | TSHR 3774/4885LMNA 1014/4885NFKB1 1633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.