Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 9/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 6/20 | 0.47 |
| ▸ | GRK2 | P25098 | 5/20 | 0.47 |
| ▸ | LIG1 | P18858 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5003757 | 0.79 | KMT2A (0.50) | KMT2APOLBCTDSP1GRK2LIG1 | |
| SCHEMBL27477939 | 0.78 | KMT2A (0.58) | KMT2APOLBCTDSP1GRK2LIG1 | |
| SCHEMBL20743688 | 0.77 | MMP1 (0.66) | KMT2APLCG1SMN1; SMN2MEN1 | |
| SCHEMBL4351497 | 0.76 | KMT2A (0.61) | KMT2APOLBCTDSP1GRK2LIG1 | |
| SCHEMBL22333253 | 0.74 | ALDH1A1 (0.67) | KMT2APOLBPLCG1HSD11B1SMN1; SMN2 | |
| SCHEMBL5106212 | 0.74 | HDAC3 (0.46) | KMT2APOLBCTDSP1MEN1 | |
| SCHEMBL5735887 | 0.72 | KMT2A (0.43) | KMT2AGRK2SMN1; SMN2MEN1 | |
| SCHEMBL5285711 | 0.70 | L3MBTL1 (0.58) | HSD11B1L3MBTL1KDM4E | |
| SCHEMBL13586189 | 0.70 | PLCG1 (0.61) | KMT2APOLBCTDSP1GRK2LIG1 | |
| SCHEMBL1938871 | 0.70 | CA2 (0.64) | KMT2APOLBCTDSP1GRK2PLCG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414063-B2 | Inhibitors of Akt (protein kinase B) | ELI LILLY AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| US-20070043040-A1 | Inhibitors of akt (protein kinase b) | ELI LILLY AND COMPANY | 2007-02-22 | — | — | US | disclosed |
| EP-1611105-A1 | ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B) | ELI LILLY AND COMPANY (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004094386-A1 | ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B) | ELI LILLY AND COMPANY (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043040-A1 | Inhibitors of akt (protein kinase b) | AKT1, AKT2, BRAF | KMT2A 2622/4885POLB 525/4885CTDSP1 1156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.