Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 3/20 | 0.31 |
| ▸ | CNR2 | P34972 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | GALR1 | P47211 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5964210 | 0.99 | AKR1B1 (0.34) | AKR1B1SSTR3BCHEACHEPDE7B | |
| SCHEMBL5963749 | 0.90 | FPR2 (0.34) | AKR1B1SSTR3FPR2CNR1CNR2 | |
| SCHEMBL5963604 | 0.89 | POLB (0.35) | AKR1B1SSTR3PDE7BKMT2AGALR1 | |
| SCHEMBL5964279 | 0.87 | AKR1B1 (0.31) | AKR1B1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5004773 | 0.87 | ALDH1A1 (0.36) | SSTR3KMT2ASLC6A4SLC6A3 | |
| SCHEMBL5963456 | 0.87 | SLC6A2 (0.36) | SSTR3PDE7BKMT2ASLC6A2SLC6A4 | |
| SCHEMBL5963816 | 0.87 | OPRM1 (0.35) | AKR1B1FPR2 | |
| SCHEMBL5963305 | 0.86 | SLC6A3 (0.39) | AKR1B1SSTR3FPR2SLC6A2SLC6A4 | |
| SCHEMBL5963556 | 0.86 | KMT2A (0.34) | PDE7BKMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5007459 | 0.86 | FPR2 (0.32) | AKR1B1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396846-B2 | Growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| US-7396846-B2 | Growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| US-7396846-B2 | Growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| EP-1497316-B1 | GROWTH HORMONE SECRETAGOGUES | LILLY CO ELI (US) | 2006-07-05 | — | — | EP | disclosed |
| US-20050240001-A1 | 2-(2-Amino-2-methylpropionylamino)-3-(2,6-difluoro-3-methylphenyl)methoxy propionic acid N-[5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-ylmethyl]-N-ethylamide; endogenous human growth hormone controller; non-peptidyl in nature, more metabolically stable | ELI LILLY AND COMPANY (US) | 2005-10-27 | — | — | US | disclosed |