Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.46 |
| ▸ | VEGFA | P15692 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29809414 | 0.70 | ACHE (0.59) | HTTLMNAMEN1KMT2AEGLN1 | |
| SCHEMBL1757848 | 0.70 | ACHE (0.59) | HTTLMNAMEN1KMT2AEGLN1 | |
| SCHEMBL14771218 | 0.69 | EGLN1 (0.49) | HTTLMNAMEN1POLBKMT2A | |
| SCHEMBL4478133 | 0.68 | MAPK14 (0.52) | HTTLMNAMEN1POLBKMT2A | |
| SCHEMBL4064145 | 0.68 | MAPK14 (0.47) | EGLN1MAPK14DHPS | |
| SCHEMBL24499451 | 0.67 | HTR6 (0.54) | HTTLMNAMEN1KMT2AEGLN1 | |
| SCHEMBL3186789 | 0.67 | MAPK14 (0.49) | HTTLMNAMEN1POLBKMT2A | |
| SCHEMBL27749451 | 0.67 | TLR8 (0.47) | HTTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL4249660 | 0.67 | DHPS (0.57) | HTTLMNAEGLN1KDM4EALDH1A1 | |
| SCHEMBL14900099 | 0.67 | EGLN1 (0.69) | HTTLMNAMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989188-A1 | THERAPEUTIC PIPERAZINES AS PDE4 INHIBITORS | Helicon Therapeutics, Inc. (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007100852-A1 | THERAPEUTIC PIPERAZINES AS PDE4 INHIBITORS | HELICON THERAPEUTICS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |