Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | INPPL1 | O15357 | 3/20 | 0.42 |
| ▸ | INPP5A | Q14642 | 3/20 | 0.42 |
| ▸ | INPP5B | P32019 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18121460 | 0.87 | ALDH1A1 (0.44) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL18114061 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL18607332 | 0.85 | KDM4E (0.43) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL19629845 | 0.84 | ALDH1A1 (0.42) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL20696702 | 0.84 | ALDH1A1 (0.42) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL18114020 | 0.83 | GLA (0.38) | CYP2C19HIF1ANPSR1RXRARXRB | |
| SCHEMBL27859933 | 0.83 | INPPL1 (0.46) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL1354464 | 0.81 | INPPL1 (0.44) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL30040484 | 0.81 | POLB (0.50) | ALDH1A1CYP2C19HIF1ANPSR1GAA | |
| SCHEMBL6892090 | 0.81 | POLB (0.50) | ALDH1A1CYP2C19HIF1ANPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017036968-A1 | ANTIBACTERIAL ANNULATED PYRROLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2017-03-09 | — | — | WO | disclosed |
| WO-2017037039-A1 | ANTIBACTERIAL HETEROCYCLIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2017-03-09 | — | — | WO | disclosed |
| US-20080287396-A1 | Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections | TARGANTA THERAPEUTICA INC. (CA) | 2008-11-20 | — | — | US | disclosed |
| EP-1881974-A2 | PHOSPHONATED FLUOROQUINOLONES, ANTIBACTERIAL ANALOGS THEREOF, AND METHODS FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | Targanta Therapeutics Inc. (CA) | 2008-01-30 | — | — | EP | disclosed |
| WO-2007017762-A2 | PHOSPHONATED FLUOROQUINOLONES, ANTIBACTERIAL ANALOGS THEREOF, AND METHODS FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | TARGANTA THERAPEUTICS INC. (CA) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287396-A1 | Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections | BPGM, PSPH, PGLS | ALDH1A1 4175/4885KDM4E 3645/4885USP2 3163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.