Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | INPPL1 | O15357 | 3/20 | 0.39 |
| ▸ | INPP5A | Q14642 | 3/20 | 0.39 |
| ▸ | INPP5B | P32019 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18607332 | 0.87 | KDM4E (0.43) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL5007401 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL18121460 | 0.83 | ALDH1A1 (0.44) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL18114061 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL19629845 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL27859933 | 0.79 | INPPL1 (0.46) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL20696698 | 0.78 | TSHR (0.36) | ALDH1A1KDM4EPTPRCMTNR1AMTNR1B | |
| SCHEMBL20696701 | 0.78 | KDM4E (0.45) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL1354464 | 0.78 | INPPL1 (0.44) | ALDH1A1KDM4EUSP2HPGDPDE3A | |
| SCHEMBL20696700 | 0.77 | MTNR1A (0.45) | ALDH1A1KDM4EUSP2HPGDPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190315731-A1 | 6-(BUTA-1,3-DIYN-1-YL)BENZO[D]THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS, LTD. (CH) | 2019-10-17 | — | — | US | disclosed |
| US-10314823-B2 | Substituted 1,2-dihydro-3H-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-06-11 | — | — | US | disclosed |
| US-20190031676-A1 | ANTIBACTERIAL ANNULATED PYRROLIDIN-2-ONE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315731-A1 | 6-(BUTA-1,3-DIYN-1-YL)BENZO[D]THIAZOLE DERIVATIVES | TMBIM6, BTN3A1, BET1 | ALDH1A1 40/4885KDM4E 3497/4885USP2 4835/4885 |
| US-10314823-B2 | Substituted 1,2-dihydro-3H-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds | MRPL21, MRM1, MT-CO1 | ALDH1A1 103/4885KDM4E 2265/4885USP2 4611/4885 |
| US-20190031676-A1 | ANTIBACTERIAL ANNULATED PYRROLIDIN-2-ONE DERIVATIVES | PYCR1, PSPH, RPSA | ALDH1A1 2350/4885KDM4E 2920/4885USP2 3008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.