Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.46 |
| ▸ | ITGAL | P20701 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 2/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6269163 | 0.73 | LMNA (0.66) | ABCG2ITGB2ICAM1ITGALLMNA | |
| SCHEMBL13950594 | 0.71 | ABCG2 (0.46) | ABCG2ITGB2ICAM1ITGALLMNA | |
| SCHEMBL438269 | 0.71 | ABCG2 (0.46) | ABCG2ITGB2ICAM1ITGALLMNA | |
| SCHEMBL279547 | 0.71 | ABCG2 (0.46) | ABCG2ITGB2ICAM1ITGALLMNA | |
| SCHEMBL29966720 | 0.71 | ABCG2 (0.46) | ABCG2ITGB2ICAM1ITGALLMNA | |
| SCHEMBL1038843 | 0.71 | ABCG2 (0.46) | ABCG2ITGB2ICAM1ITGALLMNA | |
| SCHEMBL442811 | 0.71 | ABCG2 (0.46) | ABCG2ITGB2ICAM1ITGALLMNA | |
| SCHEMBL2422652 | 0.71 | ABCG2 (0.46) | ABCG2ITGB2ICAM1ITGALLMNA | |
| SCHEMBL8674765 | 0.69 | ITGB2 (0.82) | ABCG2ITGB2ICAM1ITGALLMNA | |
| SCHEMBL15313020 | 0.68 | MAOA (0.48) | ABCG2ITGB2ICAM1ITGALLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492431-B2 | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity | JANSSEN PHARMACEUTICA, N.V. (BE) | 2013-07-23 | — | — | US | claimed |
| EP-1968573-A2 | USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MANIA AND BIPOLAR DISORDER | Janssen Pharmaceutica, N.V. (BE) | 2008-09-17 | — | — | EP | claimed |
| WO-2007075695-A2 | USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MANIA AND BIPOLAR DISORDER | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-05 | — | — | WO | claimed |