Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194246 | 0.84 | PIK3CD (0.34) | PIK3CDCYP2D6CYP2C19 | |
| SCHEMBL4594988 | 0.84 | PIK3CD (0.34) | PIK3CDCYP2D6CYP2C19 | |
| SCHEMBL5011001 | 0.83 | PIK3CD (0.32) | PIK3CD | |
| SCHEMBL5010290 | 0.71 | NAALAD2 (0.32) | — | |
| SCHEMBL4915330 | 0.70 | ALDH1A1 (0.39) | PIK3CD | |
| SCHEMBL30917993 | 0.69 | HMGCR (0.33) | — | |
| SCHEMBL26928410 | 0.67 | PIK3CD (0.41) | PIK3CDCYP2D6CYP2C19 | |
| SCHEMBL1692666 | 0.66 | KDM4E (0.32) | — | |
| SCHEMBL4596314 | 0.66 | KDM4E (0.32) | — | |
| SCHEMBL4595956 | 0.65 | MMP8 (0.39) | CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948185-A2 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007058852-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |