Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 6/20 | 0.43 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009841 | 0.83 | RXRA (0.38) | RXRARXRB | |
| SCHEMBL2586836 | 0.81 | AGXT (0.45) | BCL2PTGS2GGPS1AGXTMMP3 | |
| SCHEMBL26704195 | 0.78 | TRIM24 (0.57) | PTGS2RXRARXRBSYKDHODH | |
| SCHEMBL1420024 | 0.77 | AGXT (0.52) | BCL2PTGS2GGPS1PTPN5AGXT | |
| SCHEMBL1427894 | 0.77 | TP53 (0.40) | — | |
| SCHEMBL4517154 | 0.76 | CYP2C9 (0.48) | PTPN5RXRARXRBSYKDHODH | |
| SCHEMBL547993 | 0.76 | RXRA (0.51) | PTPN5RXRARXRBSYKDHODH | |
| SCHEMBL13186526 | 0.75 | TAAR1 (0.48) | BCL2PTGS2GGPS1AGXT | |
| SCHEMBL13985965 | 0.74 | RXRA (0.55) | PTPN5RXRARXRBDHODH | |
| SCHEMBL1513827 | 0.73 | HSD17B1 (0.54) | MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | disclosed |