SCHEMBL5011964

SCHEMBL5011964

COc1cccc(OC)c1-c1c2nc(c(-c3ccccc3)c3ccc([nH]3)c(-c3ccccc3)c3nc(c(-c4ccccc4)c4ccc1[nH]4)C=C3)C=C2

nearest known ligand 0.50

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ TERT O14746 3/20 0.49
▸ STAT3 P40763 1/20 0.48
▸ STAT1 P42224 1/20 0.48
▸ TOP1 P11387 4/20 0.48
▸ CYCS P99999 4/20 0.47
▸ ABCG2 Q9UNQ0 1/20 0.46
▸ ENPP2 Q13822 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL479431 1.00 TERT (0.49) TERTSTAT3STAT1TOP1CYCS
SCHEMBL5016668 1.00 TERT (0.49) TERTSTAT3STAT1TOP1CYCS
SCHEMBL9581910 0.91 TERT (0.45) TERTTOP1CYCSABCG2ENPP2
SCHEMBL29408466 0.91 TERT (0.45) TERTTOP1CYCSABCG2ENPP2
SCHEMBL17251727 0.90 TOP1 (0.43) TERTSTAT3STAT1TOP1CYCS
SCHEMBL17251726 0.87 TOP1 (0.58) TERTSTAT3STAT1TOP1CYCS
SCHEMBL18613121 0.85 ABCG2 (0.44) TERTTOP1CYCSABCG2ENPP2
SCHEMBL8014529 0.84 TOP1 (0.62) TERTSTAT3STAT1TOP1CYCS
SCHEMBL8014524 0.84 TOP1 (0.62) TERTSTAT3STAT1TOP1CYCS
SCHEMBL18593558 0.84 TOP1 (0.45) TERTTOP1CYCSABCG2ENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7417142-B2 Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, INC. (US) 2008-08-26 — — US disclosed
US-20060030718-A1 Cobalt-based catalysts for the cyclization of alkenes UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2006-02-09 — — US disclosed
US-20050124596-A1 Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2005-06-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060030718-A1 Cobalt-based catalysts for the cyclization of alkenes PPOX, HCCS, ICOSLG TERT 645/4885STAT3 3817/4885STAT1 4312/4885
US-20050124596-A1 Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same PPOX, PPIF, HMBS TERT 1385/4885STAT3 2986/4885STAT1 3579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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