Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.60 |
| ▸ | CYCS | P99999 | 4/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | TERT | O14746 | 4/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28167771 | 0.88 | TOP1 (0.74) | TOP1CYCSABCG2ENPP2TERT | |
| SCHEMBL27814176 | 0.83 | TOP1 (0.71) | TOP1CYCSABCG2ENPP2TERT | |
| SCHEMBL13495278 | 0.80 | CYCS (0.59) | TOP1CYCSABCG2ENPP2TERT | |
| SCHEMBL13495256 | 0.80 | TOP1 (0.63) | TOP1CYCSABCG2ENPP2TERT | |
| SCHEMBL13495254 | 0.78 | TOP1 (0.63) | TOP1CYCSABCG2ENPP2TERT | |
| SCHEMBL30168843 | 0.77 | TOP1 (0.97) | TOP1CYCSABCG2ENPP2TERT | |
| SCHEMBL28502638 | 0.77 | TOP1 (0.97) | TOP1CYCSABCG2ENPP2TERT | |
| SCHEMBL22473799 | 0.76 | TOP1 (0.54) | TOP1CYCSABCG2ENPP2 | |
| SCHEMBL9273850 | 0.76 | TOP1 (0.72) | TOP1CYCSABCG2ENPP2TERT | |
| SCHEMBL29354037 | 0.75 | TOP1 (1.00) | TOP1CYCSABCG2ENPP2TERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470677-B2 | Oxidant scavengers | AEOLUS PHARMACEUTICALS, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| EP-0831891-B1 | OXIDANT SCAVENGERS | UNIV DUKE (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20040019031-A1 | Oxidant scavengers | DUKE UNIVERSITY | 2004-01-29 | — | — | US | disclosed |
| US-6127356-A | MODULATING INTRA- OR EXTRACELLULAR LEVELS OF OXIDANTS SUCH AS SUPEROXIDE RADICALS, HYDROGEN PEROXIDE AND PEROXYNITRITES BY USING LOW MOLECULAR WEIGHT MIMETICS OF SUPEROXIDE DISMUTASE, CATALASE OR PEROXIDASE | DUKE UNIVERSITY (US) | 2000-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019031-A1 | Oxidant scavengers | GPX4, LPO, PRDX5 | TOP1 4713/4885CYCS 232/4885ABCG2 3304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.