Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 9/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012696 | 0.89 | SIGMAR1 (0.46) | SIGMAR1HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL2091040 | 0.86 | MAOB (0.37) | KCNH2 | |
| SCHEMBL27666017 | 0.82 | SIGMAR1 (0.49) | SIGMAR1HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL27665886 | 0.76 | SIGMAR1 (0.47) | SIGMAR1HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL2091038 | 0.74 | MAOB (0.37) | KCNH2 | |
| SCHEMBL5537517 | 0.72 | SIGMAR1 (0.57) | SIGMAR1HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL5541926 | 0.72 | SIGMAR1 (0.57) | SIGMAR1HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL5539612 | 0.71 | SIGMAR1 (0.58) | SIGMAR1HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL30671730 | 0.70 | SIGMAR1 (0.73) | SIGMAR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL5013286 | 0.69 | HTR1A (0.51) | SIGMAR1HTR1AHTR2CDRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |