Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | LHCGR | P22888 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015826 | 0.90 | FAAH (0.42) | ALDH1A1RAB9AFAAHEPHX1HTT | |
| SCHEMBL5015753 | 0.90 | RAB9A (0.41) | RAB9AEPHX1 | |
| SCHEMBL5012858 | 0.88 | ALDH1A1 (0.55) | ALDH1A1RAB9AFAAH | |
| SCHEMBL5012242 | 0.88 | CHRNB4 (0.39) | ALDH1A1RAB9AKDM4EHTTHSD17B10 | |
| SCHEMBL5014462 | 0.88 | CHRNB4 (0.39) | ALDH1A1RAB9AKDM4EHTTHSD17B10 | |
| SCHEMBL5012897 | 0.87 | TRPV1 (0.42) | FAAHHTT | |
| SCHEMBL5014508 | 0.87 | EPHX2 (0.41) | ALDH1A1RAB9AFAAHEPHX1HTT | |
| SCHEMBL5130161 | 0.85 | SMN1; SMN2 (0.51) | ALDH1A1KDM4EHTT | |
| SCHEMBL5012860 | 0.83 | HTT (0.41) | KDM4EHTT | |
| SCHEMBL5128794 | 0.81 | ALDH1A1 (0.48) | ALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |