Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014508 | 0.91 | EPHX2 (0.41) | EPHX2FAAHMEN1HTTKMT2A | |
| SCHEMBL5011104 | 0.89 | LMNA (0.43) | TRPV1EPHX2HDAC4MEN1LMNA | |
| SCHEMBL5012863 | 0.89 | LMNA (0.43) | TRPV1EPHX2HDAC4MEN1LMNA | |
| SCHEMBL5012908 | 0.88 | LMNA (0.42) | TRPV1EPHX2MEN1LMNAHTT | |
| SCHEMBL5015753 | 0.87 | RAB9A (0.41) | MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL5015826 | 0.87 | FAAH (0.42) | FAAHLMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5012834 | 0.87 | ALDH1A1 (0.45) | FAAHHTT | |
| SCHEMBL5117469 | 0.87 | TRPV1 (0.44) | TRPV1EPHX2LMNA | |
| SCHEMBL5015806 | 0.84 | TRPM8 (0.40) | TRPV1EPHX2FAAH | |
| SCHEMBL5130209 | 0.83 | MAPT (0.47) | TRPV1MEN1LMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |