Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 9/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.67 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.67 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.67 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.67 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.67 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11191379 | 0.88 | CHRM1 (0.71) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL29627864 | 0.82 | CHRM1 (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL7323866 | 0.82 | CHRM1 (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL10741591 | 0.82 | CHRM1 (0.71) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL7323716 | 0.82 | CHRM1 (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL7322165 | 0.82 | CHRM1 (0.80) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL7331808 | 0.82 | CHRM1 (0.71) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL2843067 | 0.82 | CHRM1 (1.00) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL11384670 | 0.81 | ALOX12 (0.77) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL11733821 | 0.81 | CHRM1 (0.55) | CHRM1ALDH1A1PKMHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250178-B1 | IMPROVED PROCESS FOR PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES | CENTAUR CHEMICALS PVT LTD (IN) | 2012-06-20 | — | — | EP | disclosed |
| US-8106189-B2 | Process for preparation of triazol-benzodiazepine derivatives | CENTAUR CHEMICALS PVT LTD (IN) | 2012-01-31 | — | — | US | disclosed |
| EP-2250178-A2 | IMPROVED PROCESS FOR PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES | Centaur Chemicals Pvt. Ltd. (IN) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009069147-A2 | IMPROVED PROCESS FOR PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES | CENTAUR CHEMICALS PVT. LTD. (IN) | 2009-06-04 | — | — | WO | disclosed |
| US-20090093629-A1 | PROCESS FOR PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES | CENTAUR CHEMICALS PVT LTD (IN) | 2009-04-09 | — | — | US | disclosed |
| US-5753649-A | Therapeutic agent for osteoporosis and diazepine compound | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5593988-A | DIAZIPINE DERIVATIVES OF THIOPHENE FOR BONE DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-01-14 | — | — | US | disclosed |
| EP-0638560-A1 | REMEDY FOR OSTEOPOROSIS AND DIAZEPINE COMPOUND | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |
| US-4978753-A | 7-phenylpyrimido[1,2-alpha][1,4]benzodiazepin-3(5H)-ones | THE UPJOHN COMPANY (US) | 1990-12-18 | — | — | US | disclosed |
| US-4902794-A | Triazolo-benzodiazepines | THE UPJOHN COMPANY (US) | 1990-02-20 | — | — | US | disclosed |
| US-4902794-A | Triazolo-benzodiazepines | THE UPJOHN COMPANY (US) | 1990-02-20 | — | — | US | disclosed |
| US-4427590-A | Triazolobenzodiazepine derivatives | CIBA-GEIGY CORPORATION (US) | 1984-01-24 | — | — | US | disclosed |
| US-4250094-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS, AND ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-02-10 | — | — | US | disclosed |
| US-4141902-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1979-02-27 | — | — | US | disclosed |
| US-4017492-A | As-triazinobenzodiazepin-1-ones | THE UPJOHN COMPANY (US) | 1977-04-12 | — | — | US | disclosed |
| US-4012413-A | 1-(2-AMINOALKYL)-6-PHENYL-TRIAZOLO-BENZODIAZEPINE COMPOUNDS USED AS TRANQUILIZERS AND ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1977-03-15 | — | — | US | disclosed |
| US-3992408-A | CHEMICAL INTERMEDIATES | THE UPJOHN COMPANY (US) | 1976-11-16 | — | — | US | disclosed |
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3946032-A | Acetal derivatives of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde | CIBA-GEIGY CORPORATION (US) | 1976-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093629-A1 | PROCESS FOR PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES | GABBR1, GABBR2, CYP2C19 | CHRM1 1016/4885ALDH1A1 2973/4885PKM 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.